Overview

This is an introductory text intended to give the non-specialist a comprehensive insight into the science of biotransformations. The book traces the history of biotransformations, clearly spells out the pros and cons of conducting enzyme-mediated versus whole-cell bioconversions, and gives a variety of examples wherein the bio-reaction is a key element in a reaction sequence leading from cheap starting materials to valuable end-products (such as pharmaceuticals and agrochemicals, fragrances and flavours). Biotransformations involving the hydrolysis of esters, amides and nitriles, the synthesis of esters and amides, reduction and oxidation reactions and carbon–carbon bond-forming systems are discussed. The book finishes with a discussion of some industrially important large-scale bioconversions.

Full Product Details

Author:   S. M. Roberts (University of Exeter) ,  Nicholas J. Turner (University of Exeter) ,  Andrew J. Willetts (University of Exeter) ,  Michael K. Turner (University College London)
Publisher:   Cambridge University Press
Imprint:   Cambridge University Press (Virtual Publishing)
ISBN:  

9780511752254

ISBN 10:   0511752253
Publication Date:   04 August 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Undefined
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

Preface; 1. An historical introduction to biocatalysis using enzymes and microorganisms; 2. The inter-relationship between enzymes and cells with particular reference to whole-cell biotransformations using bacteria and fungi; 3. Useful intermediates and end-products obtained from whole-cell/enzyme catalysed hydrolysis and esterification reactions; 4. Useful intermediates and end-products obtained from biocatalysed oxidation and reduction reactions; 5. Useful intermediates and end-products obtained from biocatalysed carbon–carbon, carbon–oxygen, carbon–nitrogen, and carbon–chalcogen bond-forming reactions; 6. The application of biocatalysis to the manufacture of fine chemicals; Index.

Reviews

' … the book is well presented and has few errors. It is a readable and affordable introduction for those new to this area, particularly synthetic chemists, and would also be useful for an advanced undergraduate or a postgraduate course in the subject.' Chemistry in Britain

' ... the book is well presented and has few errors. It is a readable and affordable introduction for those new to this area, particularly synthetic chemists, and would also be useful for an advanced undergraduate or a postgraduate course in the subject.' Chemistry in Britain

' ... the book is well presented and has few errors. It is a readable and affordable introduction for those new to this area, particularly synthetic chemists, and would also be useful for an advanced undergraduate or a postgraduate course in the subject.' Chemistry in Britain ...I would recommend this as a good book to initiate researchers in the use of enzymes for obtaining organic compounds. Josep J. Centelles, The Biochemist ...well written and well organized....A good introductory work that will be useful for scientists in many different fields. Choice ...a comprehensive summary of numerous biological conversions including pharmaceuticals and agrochemicals, fragrances and flavors....well written and endowed with tables, figures and schemes....it could be a good textbook or backbone for a course in the developing field of biotransformations. This book deserves a place in the library of graduate and post-graduate levels as a valuable source of information on this vital area. Jean-Luc Berger, CSM Newsletter ...a flexible and well-written book that is suitable as a supplement to existing course materials in biochemistry or organic chemistry....should also be valuable as the core of a free-standing course for undergraduates, and as an entry to the working chemist or biologist interested in exploring this area for the first time. Manuel A. Navia, Quarterly Review of Biology This book is clearly written and can be read from cover to cover in less than a day. It is suitable as supplementary reading for an upper-level undergraduate or beginning graduate class in methods of organic synthesis. It would also be useful as background reading for students pursuing independent study projects involving biocatalysis. Douglas C. Cameron, Journal of the American Chemical Society

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