Overview

This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals. 

Full Product Details

Author:   Richard W. Compans ,  Michael B. A. Oldstone
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2014
Volume:   385
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   6.788kg
ISBN:  

9783319379784

ISBN 10:   331937978
Pages:   444
Publication Date:   22 September 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I: Molecular determinants of pathogenicity  The Hemagglutinin - a Determinant of Pathogenicity Eva Böttcher-Friebertshäuser, Wolfgang Garten, Mikhail Matrosovich, and Hans Dieter Klenk  Molecular determinants of pathogenicity in the polymerase complex Gülsah Gabriel and Ervin Fodor  Part II: Virus entry and cell tropism  Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range Xiaoli Xiong, John W. McCauley, David A. Steinhauer  Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology Charles J. Russell Part III: Transmission and Pandemics  Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT) Nancy J. Cox, Susan C. Trock and Stephen A. Burke  Avian influenza virus transmission to mammals S. Herfst, M. Imai, Y. Kawaoka and R.A.M. Fouchier  Transmission in the Guinea Pig Model Anice C. Lowen, Nicole M. Bouvier and John Steel  Enhancement of influenza virus transmission by gene reassortment Chengjun Li and Hualan Chen  Swine and Influenza: A Challenge to One Health Research Robert E. Kahn, Wenjun Ma and Jürgen A. Richt  Part IV: Animal models and pathogenesis  Influenza Pathobiology and Pathogenesis in Avian Species Monique S. Franҫa and Justin D. Brown  Molecular determinants of influenza virus pathogenesis in mice Ram P. Kamal, Jaqueline M. Katz, and Ian A. York  Mammalian models for the study of H7 virus pathogenesis and transmission Jessica A. Belser and Terrence M. Tumpey  Pathogenesis and vaccination of influenza A virus in swine Daniela S. Rajao, Tavis K. Anderson, Phillip C. Gauger, Amy L. Vincent  Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis Amber M. Smith and Jonathan A. McCullers   Part V: Evolution, Antigenic Variation  Evolution and Ecology of Influenza A viruses Sun-Woo Yoon, Richard J. Webby and Robert G. Webster  Influenza A virus reassortment John Steel and Anice C. Lowen  Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses Ruben O Donis

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Author Information

Richard W. Compans is a Professor of Microbiology and Immunology and Scientific Director of Influenza Pathogenesis and Immunology Research Center, Emory University, School of Medicine, Atlanta, GA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology. Michael B.A. Oldstone is a Professor at the Department of Immunology and Microbial Science at the Scripps Research Institute, La Jolla, CA, USA and a series editor and volume editor of several volumes with Current Topics in Microbiology and Immunology.

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