Overview

"Bacterial CpG-DNA sequences not only serve for genetic information but act as ""danger"" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as ""natural"" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field."

Full Product Details

Author:   H. Wagner
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 2000
Volume:   247
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   0.406kg
ISBN:  

9783642640773

ISBN 10:   364264077
Pages:   246
Publication Date:   26 September 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

List of Contents.- Mechanism of Action of CpG DNA.- Oligodeoxyribonucleotides with 5’-ACGT-3’ or 5’-TCGA-3’ Sequence Induce Production of Interferons.- Macrophage Activation by Immunostimulatory DNA.- Consequences of Bacterial CpG DNA-Driven Activation of Antigen-Presenting Cells.- Signal Transduction Pathways Activated by CpG-DNA.- CpG DNA Co-Stimulates Antigen-Reactive T Cells.- Role of Type I Interferons in T Cell Activation Induced by CpG DNA.- Hematopoietic Remodeling Triggered by CpG DNA.- CpG DNA Augments the Immunogenicity of Plasmid DNA Vaccines.- The Role of Bacterial DNA in Autoantibody Induction.- CpG DNA in Cancer Immunotherapy.- Use of CpG DNA for Enhancing Specific Immune Responses.- Immunostimulatory-Sequence DNA is an Effective Mucosal Adjuvant.- CpG DNA Switches on Th1 Immunity and Modulates Antigen-Presenting Cell Function.- Effects of CpG DNA on Th1/Th2 Balance in Asthma.- Responses of Human B Cells to DNA and Phosphorothioate Oligodeoxynucleotides.

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