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Author:   Paike Jayadeva Bhat
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2008 ed.
Dimensions:   Width: 15.50cm , Height: 1.40cm , Length: 23.50cm
Weight:   0.524kg
ISBN:  

9783540740148

ISBN 10:   3540740147
Pages:   220
Publication Date:   29 January 2008
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
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Table of Contents

Introduction. An overview. Yeast is a eukaryotic model organism. A cell as a biochemical entity.- Adaptation to Environment. Growth and multiplication. Enzyme adaptation. Induction to Leloir enzymes.- Genetic Dissection of Galactose Metabolism. Genetic analysis of GAL regulon. Genetic mapping of GAL genes.- Genetic Analysis GAL Genetic Switch. Negative control by the repressor. Operator repressor model of GAL regulon. Genetic interactions. Conditional lethal mutations. Revised model of GAL genetic switch. Signal transduction in GAL regulon.- Molecular Genetics of GAL Regulon. Cloning: a perspective. Genomic organization of GAL cluster. Isolation of GAL4: the transcriptional activator. Isolation of GAL80: the repressor. Isolation of GAL3: the signal transducer.- Signal Transduction Revisited. Revised model of signal transduction. Genetic dissection of signal transduction.- Versatile Galactose Genetic Switch. Transcription activation. Glucose repression. Fine regulation of GAL genetic switch.- Paradigmatic Role of Galactose Switch. GAL regulon and genomics. GAL regulon and systems biology. Galactose metabolism and evolution. GAL Switch as a tool. Lessons learned.

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