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OverviewCryptococcus neoformans is an encapsulated fungal pathogen that is remarkable for its ability to cause central nervous system (CNS) infections especially in patients with AIDS. Increasing evidence suggests that microglia play a central role in the host response in cryptococcal meningoencephalitis. However, the mechanism by which microglia regulate the inflammatory process is poorly understood. We studied the microglial Fc receptor activation in response to C. neoformans-mAb challenge and showed that Fc?R activation is a powerful means of microglial gene induction. We also showed that distinct FcR subtypes and signaling pathways are involved in phagocytosis and chemokine expression. Our results thus indicate that antibody-deficiency can lead to inadequate phagocyte activation and insufficient inflammatory cell recruitment to the CNS. As the biological activity of C. neoformans immune complex in microglia was attributable to the activation of microglial FcR, our study has implications beyond cryptococcal infection in which antibody (natural or administered) can encounter antigens within the CNS. Full Product DetailsAuthor: Xianyuan SongPublisher: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Imprint: VDM Verlag Dr. Muller Aktiengesellschaft & Co. KG Dimensions: Width: 15.20cm , Height: 0.80cm , Length: 22.90cm Weight: 0.213kg ISBN: 9783639175745ISBN 10: 3639175743 Pages: 138 Publication Date: 31 July 2009 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In Print This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |