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OverviewPeste des petits ruminants is an acute and highly contagious viral disease of small ruminants which is characterized by high fever, ocular and nasal discharge, pneumonia, necrosis and ulceration of the mucuous membrane and inflammation of the gastro-intestinal tract leading to severe diarrhoea and high mortality. Clinical PPR is confirmed in Ethiopian goats, however, its circulation in other animals has never been described. In this work, we showed that antibody seroprevalence in camel, cattle, goat and sheep confirmed natural transmission in these animals without clinical disease. Virulence of PPRV was monitored in cell culture system and the use of virus specific monoclonal antibodies that enabled to detect differences in virulence between PPRV and RPV. The difference in infectivity of PPRV and RPV may have depended on the H protein epitopes and their cellular receptors. We decided to compare the amino acid epitope of H protein of PPRV with that of other morbilliviruses. We have sequenced and compared genome and antigenome promoters of a vaccine strain with field strains of PPRV. Alignment of the genome promoter sequences revealed seven nucleotide mutations at certain positio Full Product DetailsAuthor: Abraham GopiloPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 1.30cm , Length: 22.90cm Weight: 0.327kg ISBN: 9783659612435ISBN 10: 365961243 Pages: 220 Publication Date: 11 November 2014 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |