Overview

Enhancement of drug absorption represents a science that offers knowledge and elegant tools for the design and development of efficient drug products and new therapies intended for different administration routes. Today, the use of enhancers is a recognized means for solving issues of low bioavailability of traditional drugs, as well as for delivering new bio-macromolecules, which have difficulty breeching the various absorption body barriers. While extensive information exists on the various enhancers investigated for facilitating the noninjectable administration of drugs, until now the specific details have remained scattered throughout the literature.Organized by routes of administration, the book is divided into eight major sections: oral, rectal, buccal/sublingual, dermal/transdermal, nasal, vaginal/uterine, ocular, and brain. It offers fundamental as well specialized information including current findings on - surfactant use to accelerate macromolecule input; targeted gastrointestinal delivery and enhanced absorption of lipophilic drugs; permeation issues in rectal absorption; chemical means of enhancement; carriers for enhanced delivery to and across the skin; methods associated with breaching the skin; promoted buccal and sublingual absorption; emerging ocular, nasal, vaginal, and uterine delivery systems; and carriers for overcoming the blood brain barrier. Those investigators primarily involved with one specific route of delivery will be able to learn of helpful concepts and find additional stimulation from reading the approaches others have used within and outside their own spheres of activity. Readers are likely to find the same enhancer tested for various administration routes and in diverse experimental models. By understanding the properties and behavior of the enhancers operating within such systems, they may well find the inspiration needed to develop appropriate enhancing delivery methods for new applications.

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9786610732814

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