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OverviewThe ideal place to begin researching any question involving drug metabolism and interactions The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction within the human body. This six-volume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written and edited by leading international experts in the field. By collecting and reviewing the current literature in the field in one expertly organized work, this encyclopedia is the ideal place to begin researching any question involving drug metabolism and interactions. Readers will find such important topics and working tools as: Inhibited or induced enzymes and their impact on drug toxicity and altered response in both animal and human models Effects of both genetic and non-genetic factors on drug metabolism Relationships between a drug metabolism, its activation or inactivation, and a drug's potential toxicity/safety Examples demonstrating all aspects of drug metabolism and interactions in silico, in vitro, in laboratory animals, and in humans Methods and protocols enabling readers to perform seamless studies of metabolism and drug interactions All articles are based on recent findings and standards of practice. By reviewing and contextualizing the current literature, the authors offer new perspectives on our current state of knowledge as well as future directions for research in drug metabolism and interactions. References at the end of each article serve as a gateway to the literature. The Encyclopedia of Drug Metabolism and Interactions is recommended for researchers, physicians, and students at all levels. It introduces the basics to novices and explores the latest science and applications for more experienced investigators. Full Product DetailsAuthor: Alexander V. LyubimovPublisher: John Wiley & Sons Inc Imprint: John Wiley & Sons Inc Dimensions: Width: 18.50cm , Height: 3.80cm , Length: 26.00cm Weight: 1.433kg ISBN: 9781118149799ISBN 10: 1118149793 Pages: 836 Publication Date: 30 November 2012 Audience: Professional and scholarly , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In stock  We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsContributors ix Preface to the Encyclopedia xxiii Preface?Volume 6 xxvii PART X Clinical Aspects of Drug Metabolism and Interactions 1 1 Clinical Aspects of Drug Biotransformation: An Overview 3 Michael D. Coleman and Louis L. Radulovic 2 CYP450 Enzymes in Drug Discovery and Development: An Overview 53 Lin Xu, Biplab Das, and Chandra Prakash 3 DDI Risk Assessment and Evaluation in Pharmaceutical Development: Interfacing Drug Metabolism and Clinical Pharmacology 89 Karthik Venkatakrishnan 4 Current and Future Tools for Predicting Clinical Drug?Drug Interactions 151 Peter L. Bullock and Olga V. Trubetskoy 5 Predicting Human Biotransformation Pathways 177 Shelby Anderson, Debra Luffer-Atlas, and Mary Pat Knadler 6 Conjugation, Transport, and Elimination of Drugs in Humans 205 Ronald E. Savage 7 Role and Clinical Consequences of Human UDP-Glucuronosyltransferases 243 Deepak K. Dalvie and Cho-Ming Loi 8 Herb?Drug and Food?Drug Interactions 279 Martin S. Lennard 9 Effects of Liver Disease on Drug Metabolism in Humans 307 Hui-Hui Tan and Thomas D. Schiano 10 Role of Phase I Metabolism in Drug Activation and Clinical Treatment Outcomes 353 Bernard Testa and André Pannatier 11 Role of Metabolism in Toxicity of Drugs in Humans 377 Amit S. Kalgutkar and Jonathan N. Bauman 12 Idiosyncratic Drug Reactions and the Potential Role of Metabolism 403 Jack P. Uetrecht PART XI Metabolism of Specific Drug Groups and Patient Populations 455 13 Metabolism of Psychotropic Drugs 457 Julia Stingl, Jessica Oesterheld, and Miia Turpeinen 14 Metabolism-Based Consequences of Polytherapy with Antiepileptic Drugs 473 Philip N. Patsalos 15 Oral Chemotherapeutic Agents 499 Shin Ogita, Patricia LoRusso, and Jing Li 16 Drug Metabolism and Interactions in Pediatric Patients 537 Souzan Yanni and Karel Allegaert 17 Population-Based Pharmacokinetic Modeling and Simulation 581 Frédéric Y. Bois and Masoud Jamei 18 Clinical Pharmacology in Drug Labeling. The Impact of Drug Metabolism and Clinical Pharmacology on Recommended Dose of Drugs 609 Stuart Dombey Index 621ReviewsThis one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries -- a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago). ( Book News , 1 February 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013) This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries -- a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago). ( Book News , 1 February 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013) Author Information"ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including ""Frontiers of Pharmacology and Toxicology,"" which he also organized." Tab Content 6Author Website:Countries AvailableAll regions |
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