Overview

The ideal place to begin researching any question involving drug metabolism and interactions The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction within the human body. This six-volume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written and edited by leading international experts in the field. By collecting and reviewing the current literature in the field in one expertly organized work, this encyclopedia is the ideal place to begin researching any question involving drug metabolism and interactions. Readers will find such important topics and working tools as: Inhibited or induced enzymes and their impact on drug toxicity and altered response in both animal and human models Effects of both genetic and non-genetic factors on drug metabolism Relationships between a drug metabolism, its activation or inactivation, and a drug's potential toxicity/safety Examples demonstrating all aspects of drug metabolism and interactions in silico, in vitro, in laboratory animals, and in humans Methods and protocols enabling readers to perform seamless studies of metabolism and drug interactions All articles are based on recent findings and standards of practice. By reviewing and contextualizing the current literature, the authors offer new perspectives on our current state of knowledge as well as future directions for research in drug metabolism and interactions. References at the end of each article serve as a gateway to the literature. The Encyclopedia of Drug Metabolism and Interactions is recommended for researchers, physicians, and students at all levels. It introduces the basics to novices and explores the latest science and applications for more experienced investigators.

Full Product Details

Author:   Alexander V. Lyubimov
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 17.30cm , Height: 5.40cm , Length: 26.20cm
Weight:   1.839kg
ISBN:  

9781118149744

ISBN 10:   1118149742
Pages:   600
Publication Date:   26 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

Contributors xi Preface to the Encyclopedia xxv Preface?Volume 2 xxix PART III General Principles of ADME. Drug Transporters and Other Mechanisms of Transport 1 1 ADME Profiling in Drug Discovery and Development: An Overview 3 Tonika Bohnert and Chandra Prakash 2 Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption 45 John M. DeSesso, Catherine F. Jacobson, and Amy Lavin Williams 3 Oral Absorption: from Physiology to Regulatory 81 Fran Berlioz-Seux 4 General Principles of Drug Distribution 107 Gillian C. Wallace, Diane B. Ramsden, and M. Helen Grant 5 ABC Drug Transporters and Their Impact on Drug Disposition/Drug Sensitivity and Resistance 155 Steven J. Wolf and Caroline G. Lee 6 Solute Carrier (SLC) Family Transporters 195 Jasminder Sahi, Yurong Lai, and Caroline Lee 7 Mechanisms of Drug Metabolism 247 Robert S. Foti, Dan A. Rock, Larry C. Wienkers, and Jan L. Wahlstrom 8 Extrahepatic Drug-Metabolizing Enzymes and Their Significance 315 Shalu Jhajra, Ninad Ramesh Varkhede, Deepak Suresh Ahire, Bukke Vidyasagar Naik, Bhagwat Prasad, Jyoti Paliwal, and Saranjit Singh 9 Mass Balance Studies in Animals and Humans 415 Tsuhan Lin, Tycho Heimbach, Rakesh Gollen, and Handan He 10 Bioavailability and Bioequivalence 455 Benny M. Amore 11 Interspecies Pharmacokinetic Scaling and the Prediction of Human Pharmacokinetics Using Animal and Cell Models 495 Meihua Rose Feng, Nan Zheng, Xinyuan Zhang, Yea Min Huh, and Jing-yu Yu 12 The Significance and Determination of Plasma Protein Binding 531 Anagha A. Damre and Krishna R. Iyer 13 Excretion Systems 549 Kazuya Maeda and Yuichi Sugiyama 14 Pharmacokinetics and Toxicokinetics in Drug Discovery and Development 581 Manthena V. S. Varma, Zaher A. Radi, Charles J. Rotter, John Litchfield, and Ayman F. El-Kattan 15 Pharmacokinetic Data Analysis and Modeling of ADME Processes 599 Steven Zhang 16 Physiologically Based Pharmacokinetic (PBPK) Modeling: Usefulness and Applications 637 Han-Joo Maeng, Edwin C. Y. Chow, Jianghong Fan, and K. Sandy Pang 17 Pharmacodynamics 685 Indranil Rao, Vinay HK, and Sandhya Mandlekar 18 Translational Drug Discovery Research: Integration of Medicinal Chemistry, Computational Modeling, Pharmacology, ADME, and Toxicology 737 Subrahmanyam Vangala, Jakir Pinjari, Prashant Patole, Selvan Ravindran, Rajeev Gangal, Pralhad Wangikar, Sudipta Basu, Tausif Ahmed, and Himanshu Rastogi PART IV ADME of Some Specific Groups of Drugs and Delivery Systems 791 19 ADME of Herbal Dietary Supplements 793 Sheela PaiBir and Sadayappan V. Rahavendran 20 ADME of Anticancer Drugs 841 Hiroshi Yamazaki 21 ADME of Cardiovascular Drugs 855 Hong Liu and Richard Voorman 22 Disposition of Biological Therapeutics: Monoclonal Antibodies, Proteins, and Peptides 895 Dan A. Rock, Larry C. Wienkers, and Marc W. Retter 23 ADME of Natural Toxins 917 Vanessa González-Pérez and David J. Kroll 24 Influence of Changes in Physiology, Transporters, and Enzyme Expression on Disposition and Metabolism of Drugs during Pregnancy and Clinical Implications 933 Shalu Jhajra, Saranjit Singh, Karsten A. Holm, Ali Said Faqi, and Jasminder Sahi Index 963

Reviews

This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries -- a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago). ( Book News , 1 February 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013)

This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries -- a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago). ( Book News , 1 February 2013) Summing Up: Recommended. Graduate students through professionals/practitioners. ( Choice , 1 March 2013)

Author Information

"ALEXANDER V. LYUBIMOV, MD, PhD, DABT, is Director of the Toxicology Research Laboratory and Associate Professor of Pharmacology at the University of Illinois at Chicago. He has more than thirty years of experience in the fields of toxicology, bioanalytical chemistry, and drug efficacy. He has presented his research results at more than fifty national and international scientific conferences. In addition, he has published more than 140 scientific publications in peer-reviewed journals, books, and conference proceedings. Dr. Lyubimov has served as chair or president of several international conferences, including ""Frontiers of Pharmacology and Toxicology,"" which he also organized."

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