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OverviewThe conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar- maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera- peutic entities, as evidenced by Sir James Black's H -receptor an- 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex- pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy- chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de- velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need. Full Product DetailsAuthor: Michael Williams , Jeffrey B. Malick , Jeffrey B MalickPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: Softcover reprint of the original 1st ed. 1987 Dimensions: Width: 15.50cm , Height: 2.40cm , Length: 23.50cm Weight: 0.712kg ISBN: 9781461291800ISBN 10: 1461291801 Pages: 448 Publication Date: 30 September 2011 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsOverview.- Drug Discovery and Development: Reflections and Projections.- Compound Discovery.- Drug Design.- Computer-Based Approaches to Drug Design.- Use of Intact Tissue Preparations in the Drug Discovery Process.- Neuropsychopharmacological Drug Development.- Biochemical Approaches for Evaluating Drug—Receptor Interactions.- Drug Discovery at the Enzyme Level.- EEG, EEG Power Spectra, and Behavioral Correlates of Opioids and Other Psychoactive Agents.- Immunopharmacological Approaches to Drug Development.- Toxicological Evaluation and Clinical Aspects.- Toxicological Evaluation of Drugs.- Drug Delivery Systems.- Clinical Evaluation of Drug Candidates.- Therapeutic Entities—From Discovery to Human Use.- Cimetidine and Other Histamine H2-Receptor Antagonists.- Atypical Psychotropic Agents: Trazodone and Buspirone.- Calcium Channel Antagonists.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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