Overview

Timothy Gaginella and Antonio Guglietta bring together hands-on experts to critically review the many promising new areas of gastrointestinal pharmacology at the molecular level. Key chapters discuss such major themes as cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways in the gut, and the influence of cytokines on inflammatory bowel disease, as well as new opportunities for pharmacotherapy, including peptide growth factors, achykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. Also examined as possible sites for treating motility disorders and visceral pain are the opioid receptors residing in the gut, and the H3-receptor agonists for treating gut inflammation and pain. Drug Development: Molecular Targets for Gastrointestinal Disease provides a comprehensive review of today's molecular pharmacological approaches to the discovery and development of novel drugs for gastrointestinal and liver diseases.

Full Product Details

Author:   Timothy S. Gaginella ,  Antonio Guglietta
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of hardcover 1st ed. 2000
Dimensions:   Width: 15.20cm , Height: 1.60cm , Length: 22.90cm
Weight:   0.430kg
ISBN:  

9781617370878

ISBN 10:   1617370878
Pages:   278
Publication Date:   05 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 The Arachidonic Acid Pathway: New Molecules and Enzymes.- 2 Therapeutic Implications of the Nitric Oxide Pathway in Gastrointestinal Diseases.- 3 Cytokines: Opportunities for Therapeutic Intervention.- 4 Peptide Growth Factors in Gastrointestinal Disorder Therapeutics.- 5 Tachykinins: From Basic Concepts to Therapeutic Implications.- 6 CCKA Receptors in Gastrointestinal Disorders: New Therapeutic Implications.- 7 5-HT3/5-HT4 Receptors in Motility Disorders: New Therapeutic Agents.- 8 Opioid Receptors: Targets for New Gastrointestinal Drug Development.- 9 The Histamine H3 Receptor: Pharmacotherapy Targets in Gastrointestinal Disorders.

Reviews

The book focuses on specific molecules and the drugs that act on them, their receptors, metabolism or synthesis... a useful text for investigators of GI function and for pharmacologists interested in therapeutic compounds, their actions and targets. -Trends in Pharmaceutical Sciences

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