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OverviewThis book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry. Full Product DetailsAuthor: Yuichi KobayashiPublisher: Springer Verlag, Singapore Imprint: Springer Verlag, Singapore Edition: 1st ed. 2019 Weight: 0.693kg ISBN: 9789811362460ISBN 10: 9811362467 Pages: 355 Publication Date: 15 August 2020 Audience: Professional and scholarly , College/higher education , Professional & Vocational , Postgraduate, Research & Scholarly Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of Contents1. Microbial Fraction Library: A Screening Source for Drug Discovery Toshihiko Nogawa, Julius Adam V. Lopez, and Hiroyuki Osada 2. Efficient Total Synthesis of Ōmura Natural Products Toshiaki Sunazuka, Tomoyasu Hirose and Satoshi Ōmura 3. Enantioselective Total Synthesis of the Antitumor Polycyclic Natural Products, FR182877 and Taxol Masahisa Nakada 4. Synthetic Approaches on the Pluramycin-class Antibiotics Yoshio Ando, Kei Kitamura, Takashi Matsumoto and Keisuke Suzuki 5. Recent Progress Toward the Total Synthesis of Duocarmaycins A and SA, Yatakemaycin, and PDE-I and –II Juri Sakata and Hidetoshi Tokuyama 6. Structure-Activity Relationship Studies of Maitotoxin Based on Chemical Synthesis Tohru Oishi 7. Substitution of Allylic Picolinates with Various Copper Reagents and Synthetic Applications Yuichi Kobayashi and Miwa Shimoda 8. Total Synthesis of Ingenol Tyler F. Higgins and Jeffrey D. Winkler 9. Strategies for Synthesis of Anti-inflammatory Metabolites of Unsaturated Fatty Acids Yuichi Kobayashi and Masao Morita 10. Biosynthesis, biological functions, and receptors of leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid Toshiaki Okuno and Takehiko Yokomizo 11. Synthesis of classical/non-classical hybrid cannabinoids and related compounds Thanh C. Ho and Marcus A. Tius 12. Exploring bioactive marine natural products and identification of their molecular targets Masayoshi Arai 13. Target protein chemical modification Hiroyuki Nakamura 14. Target Identification of Bioactive Compounds by Photoaffinity Labeling Using Diazido Probes Suguru Yoshida and Takamitsu HosoyaReviewsAuthor InformationYuichi KOBAYASHI received Ph.D. from the Tokyo Institute of Technology in 1981. His supervisors were Professors Jiro Tsuji and Fumie Sato at the Tokyo Institute of Technology and Gibert Stork at Columbia University. He is a full Professor at Tokyo Institute of Technology. His research interests include organic synthesis using transition metal catalysts and developments of chiral C–C bond formation. Targets include fatty acid metabolites known as resolvins and leukotrienes, isoprostanes, epi-jasmonates, tetrahydrocannabinoids, cinchona alkaloids, phoslactomycins, etc. The picolinoxy leaving group in allylic substitution has created tertially and quaternary carbons. These achievements have been published in internationally renowned journals such as Angew. Chem. Int. Ed., Org. Lett., Nature, Chem. Eur. J. He has 35 years of teaching experience at the Tokyo Institute of Technology. Tab Content 6Author Website:Countries AvailableAll regions |
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