Overview

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan­ ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula­ tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN­ CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem­ agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.

Full Product Details

Author:   W. Arber ,  W. Braun ,  F. Cramer ,  R. Haas
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1972
Volume:   59
Dimensions:   Width: 17.00cm , Height: 1.40cm , Length: 24.40cm
Weight:   0.462kg
ISBN:  

9783642654466

ISBN 10:   3642654460
Pages:   258
Publication Date:   15 November 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Paramyxovirus Replication.- Viral and Bacterial Neuraminidases.- On the Origin of Pandemic Influenza Viruses.- Physiological and Genetic Studies of Polyoma Virus.- Antigen Recognition by B and T Lymphocytes.- Genetic Control of Immune Responses.- Author Index.

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