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OverviewControversies in Vaccine Safety: A Critical Review covers the topic of the safety of vaccines, an area that is often assumed rather than demonstrated. Further, indications that any vaccine may have adverse effects tend to be downplayed in context to presumed vaccine effectiveness against infectious disease. In reality, some vaccines have much better safety profiles than others and the cumulative safety impact of multiple vaccinations may be different than a simple combination of individual vaccines. The latter point becomes more significant as western medicine adds more vaccines to the recommended schedule each year. Most of the existing mainstream literature tends to be both narrowly focused and dismissive of concerns about adverse effects. The latter is particularly problematic in cases where effectiveness has not been well established. Full Product DetailsAuthor: Christopher A. Shaw (Department of Ophthalmology and Visual Science, The University of British Columbia, BC, Canada) , Claire Dwoskin (A.J. Dwoskin & Associates, USA) , Lluis Lujan (Senior Lecturer in Veterinary Pathology, Department of Animal Pathology at the University of Zaragoza, Spain) , Lucija Tomljenovic (University of British Columbia, Canada)Publisher: Elsevier Science Publishing Co Inc Imprint: Academic Press Inc ISBN: 9780128032541ISBN 10: 0128032545 Pages: 480 Publication Date: 26 October 2017 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1. Vaccine safety concerns: separating fact from fiction 2. Vaccine effectiveness: several views from the historical record 3. Vaccines as tools against infectious diseases in veterinary medicine 4. Vaccines and Autoimmunity 5. Dietary, infectious and vaccine antigens and toxic metals as contributors of autoimmunity 6. Vaccine components and host interactions: genetics, epigenetics, antigenic load and compromised immunity 7. Low dose thimerosal (ethyl-mercury) neurotoxicity and vaccines 8. Vaccine Induced Allergies 9. Immunotoxicology of vaccine adjuvants 10. Aluminum adjuvants 11. Aluminium adjuvant alternatives: a chemist's point of view 12. Characterization and pathophysiology of macrophagic myofasciitis syndrome 13. Neurodevelopmental toxicity associated with the use of aluminum vaccine adjuvants 14. Immunotoxicity of nanoparticles: implication in vaccine adjuvant use 15. Alternatives to current adjuvants 16. The significance of heterologous immunity in shaping immune responses to vaccinations and infections: a double edged sword 17. Controversies in Vaccines safety, Adjuvants and ASIA syndrome 18. Vaccine safety in veterinary practice 19. Over-immunization in sheep and associated neurodegenerative syndromes 20. Adverse reactions associated with HPV vaccines: examination of epidemiological studies and pharmacovigilance data 21. HPV vaccine and orthostatic hypotension 22. Research on drugs and vaccines: a call for formal study of drug harm 23. Seeking the correct balance between vaccine social benefits versus individual adverse effects 24. New classification of vaccine adverse events causality criteria by the WHO 25. HPV vaccine and ovarian failure: deficiencies in the clinical trial study design and vaccine surveillance systems reporting guidelines which impede accurate assessment of vaccine-related risks 26. Reanalysis of the U.S CDC data on the timing of the first MMR vaccine and autism incidence 27. The role of institutional scientific misconductReviewsAuthor InformationDr. Christopher Shaw is a Professor in the Department of Ophthalmology and Visual Sciences at the University of British Columbia and holds cross appointments with the Department of Experimental Medicine and the Graduate Program in Neuroscience. He is the author of more than 100 peer-reviewed articles as well as numerous book chapters and special reviews. Shaw has edited four books on neuroscience themes. The main focus of his research has been on the Guamanian neurological disease spectrum, ALS-parkinsonism dementia complex (ALS-PDC). Recent work in the laboratory has developed animal models of the disease that are able to recapitulate all the essential behavioural and pathological features. Work in the laboratory also provided one of the first models of aluminum adjuvant-induced neuropathology and these studies have become a new research direction. He is the founder and a former director of Neurodyn, a biotechnology company based out of Prince Edward Island. Neurodyn's efforts are directed at early phase detection and treatment for age-related neurological disorders. Claire Dwoskin is a child health advocate, philanthropist and leader of an international effort to address the increasing incidence of chronic illness and disability, including autoimmunity, and age related neurological diseases. The Dwoskin Family Foundation is supporting research in the area of adjuvant induced autoimmune diseases, including grants for basic research on factors involved in induction of autoimmune diseases in animal models. Ms. Dwoskin pursues autoimmune disease research as part of her family foundation's charitable work in the area of vaccine safety and advocacy. She is the founder of Children's Medical Safety Research Institute, a medical and scientific collaborative established to provide research funding for independent methodologically sound controlled scientific research on vaccines and their ingredients. Prominent peer-reviewed journals including Annals of Medicine, Journal of Inorganic Biochemistry, Lupus, Autoimmunity, and Vaccine have published research and articles funded by her foundation. Ms. Dwoskin is an active volunteer board member of the National Vaccine Information Center. She is the co-founder of the Vaccine Safety Conference, which was organized in part to address the acknowledged significant increases in autoimmune and autoinflammatory diseases in children and adults. She co-chaired the 2nd International Symposium on Vaccines at the 8th International Autoimmunity Congress in Granada, Spain. Dr. Lluis Lujan is a Senior Lecturer in Veterinary Pathology in the Department of Animal Pathology at the University of Zaragoza. He is an ECVP (European College of Veterinary Pathologists) board-certified veterinary pathologist and he has been involved in multiple committees of the college such as the Exam Committee and the Council. He was the President of the ECVP from 2007 to 2009. He has spent more than 30 years working in the field of ovine pathology, a field where he holds more than 50 peer-reviewed papers. Most of his studies deal with chronic sheep diseases, such as those caused by small ruminant lentiviruses (visna/maedi of sheep and caprine arthritis encephalitis) and neurodegenerative diseases caused by prions (scrapie). He has also contributed to the knowledge of non-infectious sheep processes, such as ovine amyloidosis. In 2013, he described the so-called ovine ASIA syndrome, a devastating form of secondary reaction after vaccination, observed in commercial sheep. Since then, the scientific activity of his team is devoted to the research on the topic. 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