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OverviewLisa English and a panel of expert chemical researchers have collected in Combinatorial Library Methods and Protocols a novel series of computational and laboratory methods for the design, synthesis, quality control, screening, and purification of just such combinatorial libraries. Here the reader will find cutting-edge techniques for the preparation of encoded combinatorial libraries, for the synthesis of DNA-binding polyamides, and for combinatorial receptors. There are also state-of-the-art methods for computational library design, quality control by mass spectrometry, and structure verification using 1D and 2D NMR. Full Product DetailsAuthor: Lisa B. EnglishPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: 2002 ed. Volume: 201 Dimensions: Width: 17.80cm , Height: 2.50cm , Length: 25.40cm Weight: 1.670kg ISBN: 9780896039803ISBN 10: 0896039803 Pages: 383 Publication Date: 22 August 2002 Audience: College/higher education , Professional and scholarly , Undergraduate , Professional & Vocational Format: Hardback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of ContentsLibrary Synthesis and Quality Control.- Using a Noncovalent Protection Strategy to Enhance Solid-Phase Synthesis.- Quality Control of Solid-Phase Synthesis by Mass Spectrometry.- Preparation of Encoded Combinatorial Libraries for Drug Discovery.- Simple Tools for Manual Parallel Solid Phase Synthesis.- Cleavage of Compounds from Solid Phase by Gaseous Reagents.- Synthesis of DNA-Binding Polyamides.- The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker.- Host—Guest Chemistry.- Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques.- Rapid Liquid-Phase Combinatorial Synthesis of Heterocyclic Libraries.- Soluble Polymer-Supported Methods for Combinatorial and Organic Synthesis.- Analytical Methods for Optimization and Quality Control of Combinatorial Synthesis.- Library Purification and Screening.- Resolving Racemic Mixtures Using Parallel Combinatorial Libraries.- Ligand Libraries for the Extraction of Metal Ions.- Automated Liquid-Liquid Extraction and Ion-Exchange Solid-Phase Extraction for Initial Purification.- On-Bead and Solution Screening Approaches for Genomically Derived Targets.- Computational Library Design.- Design of Virtual Combinatorial Libraries.- Approaches to Library Design for Combinatorial Chemistry.- Reagent-Based and Product-Based Computational Strategies in Library Design.- Designing Combinatorial Libraries for Efficient Screening.- Application of Neural Networks to Large Dataset QSAR, Virtual Screening, and Library Design.Reviews...an excellent work that covers many important aspects, gives easy access to literature for further study, and contains much practical advice. As it describes many different tools and techniques it is especially suitable for beginners in combinatorial chemistry, and deserves to be added to the list of well presented works in this field. Angewandte Chemie The book provides a wealth of excellent reference material and it is a worthwhile addition to the library of most medicinal chemists. - Journal of Medicinal Chemistry ...an excellent work that covers many important aspects, gives easy access to literature for further study, and contains much practical advice. As it describes many different tools and techniques it is especially suitable for beginners in combinatorial chemistry, and deserves to be added to the list of well presented works in this field. - Angewandte Chemie The book provides a wealth of excellent reference material and it is a worthwhile addition to the library of most medicinal chemists. -Journal of Medicinal Chemistry Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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