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OverviewLeading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease. Full Product DetailsAuthor: Antonio Giordano , Kenneth J. SopranoPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: Softcover reprint of hardcover 1st ed. 2003 Dimensions: Width: 15.20cm , Height: 1.90cm , Length: 22.90cm Weight: 0.499kg ISBN: 9781617372575ISBN 10: 1617372579 Pages: 326 Publication Date: 19 November 2010 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: In Print  This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us. Table of Contents1 Cdk Inhibitors: Background and Introduction.- 2 p27, A Prognostic Indicator Reflecting?....- 3 Cell Cycle Control of Transcription at the G1/S Phase Transition.- 4 Tumor-Suppressor Genes as Diagnostic Tools.- 5 Regulation of Cell Cycle and Apoptosis.- 6 CDK Inhibitors as Targets of Chemoprevention Agents.- 7 Cell Cycle Regulatory Genes as Targets of Retinoids.- 8 Modulators of Cyclin-Dependent Kinases: A Novel Therapeutic Approach for the Treatment of Neoplastic Diseases.- 9 Cell Cycle Regulators: Interactions and Their Role in Diagnosis, Prognosis, and Treatment of Cancer.- 10 Cell Cycle Regulators as Targets of Anticancer Therapy.- 11 Mammalian CDK Inhibitors as Targets of Ubiquitinization in Cancer.- 12 Synthetic Oligopeptides as Cancer Cell Cycle Modulators.ReviewsCell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention. -Pharmaceutical Research """Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention."" -Pharmaceutical Research" Cell Cycle Inhibitors in Cancer Therapy is an excellent book that summarizes the most up-to-date information on cell cycle control mechanisms, the naturally occurring and synthetic molecules that modulate cell cycle events, and their potential roles in cancer therapeutics and prevention. -Pharmaceutical Research Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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