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Held at Boppard, Germany, October 3-6, 1984

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Author:   A. Fleckenstein ,  C. Van Breemen ,  R. Groß ,  F. Hoffmeister
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1985
Volume:   9
Dimensions:   Width: 17.00cm , Height: 2.70cm , Length: 24.40cm
Weight:   0.901kg
ISBN:  

9783642705014

ISBN 10:   3642705014
Pages:   511
Publication Date:   06 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Welcome.- Calcium Antagonists and Calcium Agonists: Fundamental Criteria and Classification.- With 18 Figures and 5 Tables.- Session I: Ca-Channels.- Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists.- Ca Entry into Vascular Smooth Muscle.- Calcium Currents in Mammalian Central Neurones.- Session II: Molecular Interactions.- Chemistry of Dihydropyridines.- Structure-Function Relationships of 1,4-Dihydropyridines: Ligand and Receptor Perspectives.- Calcium Channels: Introduction into Their Molecular Pharmacology.- The Dihydropyridine Receptors.- A Proposed Pharmacological Role for Dihydropyridine Binding Sites in Heart and Coronary Smooth Muscle.- Session III: Myocardial Effects.- The Effects of 1,4-Dihydropyridine Type Ca2+-Channel Antagonists and Agonists on Intracellular [Ca2+] Transients Accompanying Twitch Contraction of Heart Muscle.- Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridines.- Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heart.- Myocardial Effects of Dihydropyridines in Patients.- Session IV: Effects on Smooth Muscle.- Effect of Dihydropyridines on Visceral Smooth Muscle.- Effects of Ca2+ Antagonists on Isolated Rabbit Mesenteric Resistance Vessels as Compared to Rabbit Aorta.- Effect of Dihydropyridine Calcium Channel Modulators on Isolated Peripheral and Cerebral Vessels.- Effects of Ca+ +-Agonistic and Ca+ +-Antagonistic 1,4-Dihydropyridine Compounds on Tonic and Phasic Activation of Extramural Coronary Vasculature.- Effects of Dihydropyridines on Human and Animal Isolated Vessels.- Endothelium-Dependent Vascular Relaxation.- Session V: Circulation.- Coronary and Systemic Hemodynamic Effects of Dihydropyridines.- Effect of a Dihydropyridine-Type Calcium Antagonist on CerebralBlood Flow and Metabolism.- Calcium, Dihydropyridines and Resistance Vessel Tone.- Differences Between Dihydropyridine and Non-Dihydropyridine Calcium Antagonists in Inotropic, Chronotropic, Dromotropic and Vascular Effects: Differences in Underlying Mechanism.- Effects of Calcium Antagonists on Fixed and Dynamic Obstructions in Patients with Severe Coronary Artery Disease.- Session VI: Hypertension.- Effects of Calcium Antagonistic and Agonistic Dihydropyridines on Experimental Hypertension and Vascular Damage.- On the Antihypertensive Properties of Nitrendipine, with Observations of Its Effects on Electrolyte Excretion.- The Use of Calcium Antagonists in the Treatment of Arterial Hypertension.- Calcium Antagonists for Identification of Mechanisms and Treatment in Patients with Essential Hypertension.- Session VII: Tissue Protection.- Dihydropyridines and the Protection of the Ischaemic and Anoxic Myocardium.- Protection Against Complete Cerebral Ischemia by Nimodipine.- Interdependence of Antihypertensive, Anticalcinotic, and Antiarteriosclerotic Effects of Calcium Antagonists — Model Experiments on Spontaneously Hypertensive Rats (SHR).

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