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OverviewCardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today. Full Product DetailsAuthor: Michael K. PugsleyPublisher: Humana Press Inc. Imprint: Humana Press Inc. Edition: Softcover reprint of the original 1st ed. 2003 Dimensions: Width: 17.80cm , Height: 2.30cm , Length: 25.40cm Weight: 0.839kg ISBN: 9781489938282ISBN 10: 1489938281 Pages: 431 Publication Date: 14 August 2013 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsCardiac Drug Development.- Novel Molecular Targets for Cardiac Drug Development.- The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery.- Oxygen Free Radicals in Heart Disease.- Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology.- Development of Anti-Inflammatory Drugs for Cardiovascular Disease.- Development and Use of Platelet Glycoprotein Antagonists in Heart Disease.- The Sodium-Hydrogen Exchange System in the Heart.- Nitric Oxide and Cardiac Ischemia.- Functional Endpoints Evaluating Cardiac Drug Activity.- Ionic Mechanisms of Atrial Fibrillation.- Targeting Ischemic Ventricular Arrhythmias.- Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease.- Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery.- Molecular Diversity of Ion Channels in the Mouse Heart.- Delayed Protection of the Myocardium.- Clinical Aspects in Cardiac Drug Development.- Cardiac Troponin Testing for Detection of Myocardial Infarction.- A Genetic Basis for Cardiac Arrhythmias.- Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy.- The Role of Pharmacometrics in Cardiovascular Drug Development.- Gender Differences in Heart Failure.- Angiogenesis Therapies for Coronary Artery Disease.ReviewsThis book provides a comprehensive overview of many advanced procedures in cardiac pharmacology that should be useful for graduate students and academic scientists as well as researchers in the pharmaceutical and biotechnology drug industries. This is an excellent book for researchers with an interest in cardiac pharmacology. Chapters address a broad spectrum of therapeutic areas and discuss appropriate molecular, biochemical, and electrophysiological in vitro as well as in vivo approaches used in the investigation of cardiovascular pharmacology. Moreover, the book addresses current clinical therapeutic trends in cardiovascular medicine. -Doody's Health Sciences Book Review Journal The scope of material covered is comprehensive, providing eclectic coverage of some very topical issues in cardiac biology and cardiac medicine...most of the chapters will be of interest to a much wider audience than pharmacologists...a worthwhile purchase. - Journal of Pharmacological and Toxicological Methods This textbook is a comprehensive look into the latest in cardiovascular drug developments and novel therapeutic agents. It covers a broad spectrum of therapeutic areas including ionic channels, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics, and gender differences in heart failure and angiogenesis therapy in coronary heart disease. It would be useful for clinical researchers and pharmacologists in cardiac drug development. Research scientists, graduate students and pharmacologists involved in both the pharmaceutical and biotechnological drug industries would benefit from this book. - E-STREAMS This book provides a comprehensive overview of many advanced procedures in cardiac pharmacology that should be useful for graduate students and academic scientists as well as researchers in the pharmaceutical and biotechnology drug industries. This is an excellent book for researchers with an interest in cardiac pharmacology. Chapters address a broad spectrum of therapeutic areas and discuss appropriate molecular, biochemical, and electrophysiological in vitro as well as in vivo approaches used in the investigation of cardiovascular pharmacology. Moreover, the book addresses current clinical therapeutic trends in cardiovascular medicine. -Doody's Health Sciences Book Review Journal The scope of material covered is comprehensive, providing eclectic coverage of some very topical issues in cardiac biology and cardiac medicine...most of the chapters will be of interest to a much wider audience than pharmacologists...a worthwhile purchase. - Journal of Pharmacological and Toxicological Methods This textbook is a comprehensive look into the latest in cardiovascular drug developments and novel therapeutic agents. It covers a broad spectrum of therapeutic areas including ionic channels, adenoviral vector delivery for cardiovascular gene therapy, pharmacometrics, and gender differences in heart failure and angiogenesis therapy in coronary heart disease. It would be useful for clinical researchers and pharmacologists in cardiac drug development. Research scientists, graduate students and pharmacologists involved in both the pharmaceutical and biotechnological drug industries would benefit from this book. - E-STREAMS Author InformationTab Content 6Author Website:Countries AvailableAll regions |
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