Overview

The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.

Full Product Details

Author:   Sho Yamasaki
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   1st ed. 2016
Dimensions:   Width: 15.50cm , Height: 1.80cm , Length: 23.50cm
Weight:   5.022kg
ISBN:  

9784431560135

ISBN 10:   4431560130
Pages:   215
Publication Date:   31 March 2016
Audience:   College/higher education ,  Professional and scholarly ,  Tertiary & Higher Education ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part 1 ITAM-coupled Activating Receptors.- 1 Dectin-2 in anti-microbial immunity and homeostasis.- 2 The function of Mincle as a danger sensor.- 3 The DAP12-Associated Myeloid C-type Lectin 5A (CLEC5A).- Part 2 HemITAM-bearing Receptors.- 4 Dectin-1 (CLEC7A, BGR, CLECSF12).- 5 DNGR-1, an F-actin-binding C-type lectin receptor involved in cross-presentation of dead cell-associated antigens by dendritic cells.- 6 C-type lectin-like receptor 2 (CLEC-2).- Part 3 ITIM-bearing Receptors.- 7 Dendritic cell immunoreceptor (DCIR): An ITIM-harboring C-type lectin receptor.- 8 Regulation and Function of the Inhibitory C-type Lectin Clec12A/MICL.- Part 4 Other receptors and related topics.- 9 DC-SIGN in infection and immunity.- 10 LOX-1 and immunity.- 11 MGL/CD301 as a unique C-type lectin expressed on dendritic cells and macrophages.- 12 Structural aspects of C-type lectin receptors.- 13 The Ligands of C-Type Lectins.

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Sho Yamasaki, PhD, Professor at Kyushu University

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