Overview

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

Full Product Details

Author:   Kenneth L. Andus ,  Thomas L. Raub
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1993
Volume:   4
Dimensions:   Width: 15.20cm , Height: 2.70cm , Length: 22.90cm
Weight:   0.760kg
ISBN:  

9781461362562

ISBN 10:   1461362563
Pages:   495
Publication Date:   24 October 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

I. Cellular Barriers.- 1 The Paracellular Pathway: A Small Version of the Kidney Nephron.- 2 Ectopeptidases.- 3 Endosomal and Lysosomal Hydrolases.- 4 Protein Uptake and Cytoplasmic Access in Animal Cells.- II. Epithelial Barriers.- 5 Transepithelial Transport of Proteins by Intestinal Epithelial Cells.- 6 Intraoral Peptide Absorption.- 7 Macromolecular Transport across Nasal and Respiratory Epithelia.- 8 Dermal Absorption of Peptides and Proteins.- 9 Rectal and Vaginal Absorption of Peptides and Proteins.- III. Vascular Barriers.- 10 Vascular Endothelial Barrier and Its Regulation.- 11 Transcytosis of Macromolecules through the Blood—Brain Fluid Barriers in Vivo.- IV. Elimination Barriers.- 12 Renal Uptake and Disposal of Proteins and Peptides.- 13 Mechanisms for the Hepatic Clearance of Oligopeptides and Proteins: Implications for Rate of Elimination, Bioavailability, and Cell-Specific Drug Delivery to the Liver.- 14 The Immune System as a Barrier to Delivery of Protein Therapeutics.- V. Tissue Barriers.- 15 Extravasation and Interstitial Transport in Tumors.- 16 Tissue Barriers: Diffusion, Bulk Flow, and Volume Transmission of Proteins and Peptides within the Brain.

Reviews

`Of the same high quality as the earlier volumes.' Trends in Pharmacological Sciences

'Of the same high quality as the earlier volumes.' Trends in Pharmacological Sciences

`Of the same high quality as the earlier volumes.' Trends in Pharmacological Sciences

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