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OverviewAspergillus fumigatus is a highly pathogenic fungus for immunocompromised patients and invasive aspergillosis exhibits mortality rates around 50-80%. Thus, the apoptosis pathway in this fungus may be an important target for the development of new drugs. From a data bank, we analyzed five different proteins (Bax, Bir, Nma111, Pca1, and Rad9) belonging to the apoptosis pathway in the genome of Aspergillus fumigatus. Phylogenetic trees, splits graphs, recombination analyses, and assessment of selection strength from codon to codon were developed to understand the evolution and the function of these proteins in the fungus. Our results suggest a conservation of these proteins in the Aspergillaceae family, as well as a low rate of gene recombination with a putative preservation of the function. We thus propose that the apoptosis pathway in Aspergillus fumigatus is started with the Rad9 protein followed by the activation of Bax and Pca1 proteins. Also, Nma111 cleaves the Bir protein resulting in the consequent activation of the Bax protein. Further studies are necessary to better understand the apoptosis process in Aspergillus fum Full Product DetailsAuthor: Natália Silva Da Trindade , Enyara Rezende Morais , Célio Dias Santos JúniorPublisher: LAP Lambert Academic Publishing Imprint: LAP Lambert Academic Publishing Dimensions: Width: 15.20cm , Height: 0.30cm , Length: 22.90cm Weight: 0.095kg ISBN: 9786202092562ISBN 10: 6202092564 Pages: 56 Publication Date: 11 September 2019 Audience: General/trade , General Format: Paperback Publisher's Status: Active Availability: In stock We have confirmation that this item is in stock with the supplier. It will be ordered in for you and dispatched immediately. Table of ContentsReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |