Overview

The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance. Our second conviction is that many research workers are all too loath to learn from the lessons of the past. For this reason we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the problems that have arisen with them in man. Some indeed may still have much to offer if they can be deployed in better ways than they are at present. This question has been taken up by several authors.

Full Product Details

Author:   R. Baurain ,  P.E. Carson ,  R. Ferone ,  C.D. Fitch
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1984
Volume:   68 / 2
Dimensions:   Width: 17.00cm , Height: 2.80cm , Length: 24.40cm
Weight:   0.927kg
ISBN:  

9783642692567

ISBN 10:   3642692567
Pages:   520
Publication Date:   07 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Antimalarial Drugs in Current Use.- 1 4-Aminoquinolines.- 2 Quinine and Quinine Analogues.- 3 8-Aminoquinolines.- 4 Sulphonamides and Sulphones.- 5 Dihydrofolate Reductase Inhibitors.- Novel Methods of Drug Development.- 6 Drug Combinations.- 7 Repository Preparations.- 8 Cell Targeting of Primaquine.- Recent Developments in Antimalarials.- 9 Drugs with Quinine-like Action.- 10 8-Aminoquinolines.- 11 Lapinone, Menoctone, Hydroxyquinolinequinones and Similar Structures.- 12 4-Aminoquinolines and Mannich Bases.- 13 Triazines, Quinazolines and Related Dihydrofolate Reductase Inhibitors.- 14 Antibiotics.- 15 Miscellaneous Compounds.- Prevention of Drug Resistance.- 16 Use of Drug Combinations.

Reviews

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions