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OverviewIn the past 5 years there has been an enormous increase of evidence that the ion channels activated by mechanical force are common to a wide variety of cell types. Mechanosensitive (MS) ion channels form a small proportion of the total channel population. They are now found in more than 30 cell types from E. coli, yeast, to plant, invertebrate, and vertebrate cells, where they occur in virtually all types of cells from bone to smooth muscle, as well as neurons. The majority of MS channels are permeable to monovalent cations and are slightly selective for K+ over Na +. How 2 ever, there are several reports of anion-selective MS channels, MS Ca + channels, and MS channels with large conductances that do not dis criminate markedly between cations and anions. Recently B. Hille has postulated possible evolutionary relationships between several types of ion channels, with mechanosensitive channels predating even the eukaryotes. Two voltage-gated channel types originate with the stem eukaryotes, as deduced from the presence of voltage-gated K+ 2 and Ca + channels in protozoa, algae, or higher plants. Agonist-gated chan nels as well as voltage-gated Na + channels appear with the earliest metazoan animals, as deduced from the presence of Na + spikes and fast chemical synapses in cnidaria (coelenterates), ctenophores, and all higher animals. Full Product DetailsAuthor: Fumio Ito , J. Adler , M. Buechner , M.W. ChapleauPublisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K Edition: Softcover reprint of the original 1st ed. 1992 Volume: 10 Dimensions: Width: 17.00cm , Height: 1.70cm , Length: 24.20cm Weight: 0.557kg ISBN: 9783642766923ISBN 10: 3642766927 Pages: 309 Publication Date: 16 December 2011 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsI Mechanosensitive Ion Channels.- 1 Mechanosensitive Ion Channels in Bacteria.- 2 Mechanosensitive Ion Channels in Yeast. Mechanisms of Activation and Adaptation.- 3 Mechanosensory Transduction in Ciliates (Protozoa).- 4 Towards Molecular Mechanism of Activation in Mechanosensitive Ion Channels.- II Mechanoreceptor Organs.- 5 Gravity Sensing by Higher Plants.- 6 Mechanoreceptors in Respiratory Systems.- 7 Cardiovascular Mechanoreceptors.- 8 Comparative Physiology of Cutaneous Mechanoreceptors.- 9 Invertebrate Auditory Receptors.- 10 Mechanoelectrical Transduction in Vertebrate Hair Cells.- 11 Muscle Mechanoreceptors in Invertebrates.- 12 Muscle Mechanoreceptors in Nonmammalian Vertebrates.- 13 Muscle Receptors in Mammals.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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