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OverviewInterest in chemical entities capable of blocking or modifying cell metabolism ultimately goes back to the discovery of the structure of DNA in the 1950s. Understanding of the biochemical processes involved in cell metabolism rapidly led to the idea that compounds could be designed which might interfere with these processes, and thus could be used in the treatment of the diseases caused by viral infection. Since then, several classes of drugs have been discovered which depend for their effect on modification of the proper functioning of nucleic acids and, with the introduction of acyclovir for the treatment of Herpes infections, nucleoside analogues have become the cornerstone of antiviral chemotherapy. The success of the early nucleoside agents, the toxicity and metabolic instability of many nucleoside analogues, and the effects of viral pathogens on public health are driving the design, synthesis and evaluation of new nucleoside analogues, with much attention turning to nucleosides containing `non natural' sugar analogues. This book focuses on the development of these agents, and draws together all the available material in an easily consulted form, which at the same time guides the reader into the research literature on the subject. Written primarily for the medicinal chemist, coverage includes both synthetic strategies and outline guidance on the main trends in biological activity. Particular attention is drawn to the comparison of synthetic routes to compounds with their natural analogues. Finally, the important antiviral activities of the compounds are treated, including anti-retrovirus, anti-hepadnavirus and anti-herpes virus properties. Written mainly for medicinal chemists in the pharmaceutical industry and synthetic organic chemists in academe, this book will also be attractive to researchers in institutions focusing on cellular metabolism. Advanced students of organic chemistry will find the clear discussion of the synthetic strategies adopted in the development of these compounds a useful introduction to this exciting and challenging area. Full Product DetailsAuthor: L. Agrofoglio , S.R. ChallandPublisher: Springer Imprint: Springer Edition: Softcover reprint of the original 1st ed. 1998 Dimensions: Width: 15.50cm , Height: 2.00cm , Length: 23.50cm Weight: 0.605kg ISBN: 9789401037341ISBN 10: 9401037345 Pages: 383 Publication Date: 07 September 2012 Audience: Professional and scholarly , Professional & Vocational Format: Paperback Publisher's Status: Active Availability: Manufactured on demand  We will order this item for you from a manufactured on demand supplier. Table of ContentsGeneral introduction.- References.- 1 The chemistry of acyclic nucleosides.- 1.1 Introduction.- 1.2 Acyclovir and its derivatives.- 1.3 Ganciclovir (DHPG) and its derivatives.- 1.4 Acyclic nucleoside phosphonate analogues.- 1.5 Seconucleosides and their derivatives.- 1.6 Miscellaneous acyclic nucleosides.- References.- 2 Biological activity of acyclic nucleosides.- 2.1 Introduction.- 2.2 Acyclovir and its prodrugs.- 2.3 Ganciclovir and its prodrugs.- 2.4 Penciclovir and famciclovir.- 2.5 Phosphonylmethoxyalkylpurines.- 2.6 HEPT.- 2.7 Allenes.- 2.8 Conclusion.- References.- 3 The chemistry of carbocyclic nucleosides.- 3.1 Introduction.- 3.2 Coupling procedures for introducing the heterocycle moiety.- 3.3 Synthesis of functionalized cyclopentylamines with ribo-, arabino-, or xylo-configurations.- 3.4 Fluorinated carbocyclic nucleoside analogues.- 3.5 Carbocycles substituted by other functional groups.- 3.6 Cyclobutyl analogues of nucleosides.- 3.7 Synthesis of cyclopropyl analogues of nucleosides.- 3.8 Cyclohexyl nucleosides.- References.- 4 Biological activity of carbocyclic nucleosides.- 4.1 Introduction.- 4.2 Inhibitors of AdoHcy hydrolase (SAH).- 4.3 Inhibitors of viral DNA replication.- 4.4 Reverse transcriptase inhibitors; carbovir and its prodrugs.- 4.5 Cyclopropyl- or cyclohexyl- analogues of nucleosides.- 4.6 Conclusion.- References.- 5 The chemistry of L-nucleosides.- 5.1 Introduction.- 5.2 Synthesis of L-nucleosides.- 5.3 Synthesis of iso-L-nucleosides.- 5.4 Summary.- References.- 6 Anti-viral activities of L-nucleosides.- 6.1 Introduction.- 6.2 Anti-viral activity of ?-L-ddNs.- 6.3 Activities of ?-L-oxothiolanyl and dioxolanyl nucleosides.- 6.4 Activity of ?-L-fluorinated nucleosides.- 6.5 Activity of miscellaneous ?-L-nucleosides.- 6.6 Conclusion.-References.- Appendix A Nomenclature of nucleosides.- Appendix B Abbreviations in widespread use.- Appendix C Glossary of terms used.- Appendix D Acknowledgements.ReviewsAuthor InformationTab Content 6Author Website:Countries AvailableAll regions |
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